基本信息：

褚宏伟 2022年8月博士毕业，于大连理工大学-中国科学院大连化学物理研究所联合培养，师从张玉奎院士、张丽华研究员与钟世钧教授。曾获得大连化学物理研究所-岛津一等博士研究生奖学金，硕士研究生一等学业奖学金等，获岛津（中国）资助参加第49届国际HPLC大会（日本京都）做口头报告。

2023年2月加入威尼斯432888cam从事教学与科研工作。2023年12月至今，在威尼斯432888cam生命科学学院从事博士后研究工作，合作导师刘少军院士。

联系方式：

邮箱：chuhongwei@hunnu.edu.cn

地址：湖南省长沙市岳麓区麓山路36号威尼斯432888cam327

研究方向：

1.蛋白质提取新方法及关键蛋白质生物功能研究

2.中药单体分离分析鉴定与功能研究

主持项目：

1.国家自然科学基金青年项目（2024-2026）

2.教育部产学合作协同育人项目（2023-2024）

3.威尼斯432888cam博士科研启动项目（2023-至今）

发表论文：

[1]Hongwei Chu, Qun Zhao, Ju Liu, Kaiguang Yang, Yanlei Wang, Jianhui Liu, Kun Zhang, Baofeng Zhao^*, Hongyan He^*, Yong Zheng, Shijun Zhong, Zhen Liang, Lihua Zhang^*, Yukui Zhang. Ionic liquid-based extraction system for in-depth analysis of membrane protein complexes.Analytical Chemistry. 2022, 94, 758-767.

[2]Hongwei Chu, Qun Zhao^*, Yichu Shan, Shen Zhang, Zhigang Sui, Xiao Li, Fei Fang, Baofeng Zhao^*, Shijun Zhong, Zhen Liang, Lihua Zhang^*, Yukui Zhang. All-ion monitoring-directed low abundance protein quantification reveals CALB2 as a key promoter in hepatocellular carcinoma metastasis.Analytical Chemistry. 2022, 94, 6102-6111（封面论文）.

[3]Hongwei Chu, Changqing Wu, Qun Zhao, Rui Sun, Kuo Yang, Baofeng Zhao^*, Yang Liu, Zhen Liang, Shijun Zhong, Lihua Zhang^*, Yukui Zhang. Quantitative proteomics identifies FOLR1 to drive sorafenib resistance via activating autophagy in hepatocellular carcinoma cells.Carcinogenesis.2021, 42, 753-761.

[4]Hongwei Chu, Pin Sun, Jiahui Yin, Guangming Liu, Yiwei Wang, Pengyao Zhao, Yizhun Zhu, Xiaohan Yang, Tiezheng Zheng, Xuezhong Zhou^*, Weilin Jin^*, Changkai Sun^*. Integrated networkanalysis reveals potentially novel molecular mechanisms and therapeutic targets of refractory epilepsies.PLoS One. 2017, 12, e0174964.

[5]Hongwei Chu, Xuezhong Zhou^*, Guangming Liu, Minghui Lv, Xiaofeng Zhou, Yiwei Wang, Lin Liu, Xing Li, Pin Sun, Yizhun Zhu, Changkai Sun^*. Network-based detection of disease modules and potential drug targets in intractable epilepsy. The 8th International Conference on Systems Biology (ISB). 2014,135-143.

[6]褚宏伟，郑诗颖，赵群，赵宝锋，梁振，张丽华^*，张玉奎，膜蛋白质复合物提取方法研究进展，分析测试学报, 2022, 41: 1387-1394.

[7] Qun Zhao^#,Hongwei Chu^#(co-first), Baofeng Zhao, Zhen Liang, Lihua Zhang^*, Yukui Zhang. Advances of ionic liquids-based methods for protein analysis.TrAC Trends in Analytical Chemistry. 2018, 108, 239-246.

[8] Zixuan Wang^#,Hongwei Chu^#(co-first), Kaiguang Yang, Baofeng Zhao^*, Zhen Liang, Lihua Zhang, Yukui Zhang. Label free quantitative proteomics analysis of the sorafenib resistance in HepG2 cells.Journal of Analysis and Testing.2021, 6:308-317.

[9]郑诗颖,褚宏伟,赵群,赵宝锋,张丽华^*,张玉奎.基于离子液体的蛋白质组样品制备新方法研究进展.中国科学：化学. 2021, 51.

[10] Guangming Liu, Huixin Wang,Hongwei Chu, Jian Yu^*, Xuezhong Zhou^*. Functional diversity of topological modules in human protein-protein interaction networks.Scientific Reports.2017, 7, 16199.

[11] Rui Sun, Chengyong Dong, Rui Li,Hongwei Chu, Jianhui Liu, Dingjun Hao, Lihua Zhang^*, Baofeng Zhao^*, Liming Wang^*, Yukui Zhang. Proteomic Analysis Reveals that EPHX1 Contributes to 5-Fluorouracil Resistance in a Human Hepatocellular Carcinoma Cell Line.Proteomics Clinical Applications. 2020, 14, 1900080.

[12] Changqing Wu, Chaoliu Dai, Xinyu Li, Mingju Sun,Hongwei Chu, Qiuhui Xuan, Yalei Yin, Chengnan Fang, Fan Yang, Zhonghao Jiang, Qing Lv, Keqing He, Yiying Qu, Baofeng Zhao, Ke Cai, Shuijun Zhang, Ran Sun, Guowang Xu, Lihua Zhang, Siyu Sun^*, Yang Liu^*. AKR1C3-dependent lipid droplet formation confers hepatocellular carcinoma cell adaptability to targeted therapy.Theranostics, 2022, 12:7681-7698.

[13] Huiming Yuan^*, Zhongpeng Dai, Xiaodan Zhang, Baofeng Zhao,Hongwei Chu, Lihua Zhang^*, Yukui Zhang. Fully automated sample treatment method for high throughput proteome analysis.Science China-Chemistry. 2021, 64, 313-321.

[14] Yiwei Wang, Hailong Liu, Yongzhong Lin, Guangming Liu,Hongwei Chu, Pengyao Zhao, Xiaohan Yang, Tiezheng Zheng, Ming Fan, Xuezhong Zhou^*, Jun Meng^*, Changkai Sun^*. Network-Based Approach to Identify Potential Targets and Drugs that Promote Neuroprotection and Neurorepair in Acute Ischemic Stroke.Scientific Reports. 2017, 7, 40137.

[15] Kuo Yang, Xuezhong Zhou^*, Runshun Zhang, Baoyan Liu, Lei Lei, Xiaoping Zhang,Hongwei Chu, Changkai Sun, Zhuye Gao, Hao Xu. Integrating Herb Effect Similarity for Network-basedHerb Target Prediction. 2015 8th International Conference on BioMedical Engineering and Informatics (BMEI 2015). 2015,483-488.

授权专利：

1.张丽华，褚宏伟，赵宝锋，马宝福，王子璇，杨开广，梁振，张玉奎，FOLR1抑制剂的应用和治疗肝癌药物混合物，ZL 202010722336.4

2.张丽华，褚宏伟，赵宝锋，杨开广，梁振，张玉奎，CALB2及定量检测CALB2的试剂的应用及工具，ZL 2019 1 0079619.9

3.孙长凯，周雪忠，杨晓寒，郑铁铮，褚宏伟，王一伟，孙品，朱依谆，陈志成，一种用于复杂大脑疾病靶向组合治疗分析的系统及方法，ZL 201510724161.X